Sumatra PDF is a PDF, ePub, MOBI, CHM, XPS, DjVu, CBZ, CBR reader for Windows

How to set origin when measuring PDF coordinates

I noticed the origin is set as the left upper corner, can I set the origin as left bottom corner

No, although a PDF input construction is defined in cartesian terms so raw page units are most frequently measured from Bottom Left (except when transformed), SumatraPDF as a multiformat renderer works consistently from screen rendered / image output page origin which is in most cases Upper Left.